Category Archive: connections
Resistance to Macrolides and Lincosamides
by Veronica Restelli Macrolides are composed of 2 or more amino or neutral sugars attached to a lactone ring of variable size. Commercially available macrolides have a 14-membered (clarithromycin, erythromycin, and roxithromycin) or 15-membered (azithromycin) lactone ring. Lincosamides (clindamycin and…
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Connections Summer 2017
VOLUME 21 NUMBER 2 SUMMER - 2017 ISSN 1496-3876 RESISTANCE TO MACROLIDES AND LINCOSAMIDES Macrolides have been in use since the early 1950s and are a major alternative to the use of…
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POLQM Quality Conference: Laboratory Quality in Challenging Times
On October 1-3, 2017 our sister program: Program Office for Laboratory Quality Management will host the 2017 Fall Quality Conference with the special theme: “Laboratory Quality in Challenging Times”. The conference will be held at the Paetzold Health Education Centre…
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Connections Spring 2017
VOLUME 21 NUMBER 1 SPRING - 2017 ISSN 1496-3876 INTRODUCING CANCAST It is important for Canada in this global environment to have an identifiable National Antibiotic Committee working with our global…
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Connections Winter 2016 – 2017
VOLUME 20 NUMBER 4 WINTER - 2016 - 2017 ISSN 1496-3876 RESISTANCE TO QUINOLONES Fluoroquinolones, especially later generation ones, have a very wide spectrum of activity. Their excellent bioavailability and seemingly favourable tolerability led to widespread use and, like other antimicrobials, misuse. Not surprisingly resistance…
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Connections Fall 2016
VOLUME 20 NUMBER 3 FALL - 2016 ISSN 1496-3876 RESISTANCE TO BETA LACTAMS Beta-lactams are a broad group of widely prescribed antibiotics characterized by a common structure, the beta-lactam ring. Shortly after the introduction of penicillin, resistant strains of staphylococci began to appear and within…
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Connections Summer 2016
VOLUME 20 NUMBER 2 SUMMER - 2016 ISSN 1496-3876 RESISTANCE IN THE GLYCOPEPTIDE ANTIMICROBIAL CLASS The glyopeptide antibiotics are cell-wall active agents that include glycopeptides, modified glycopeptides, and lipoglyopeptides. The primary mode of action of all these agents is inhibition of cell-wall synthesis in gram…
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Connections Spring 2016
VOLUME 20 NUMBER 1 SPRING - 2016 ISSN 1496-3876 GENERAL MECHANISMS OF ANTIMICROBIAL RESISTANCE IN BACTERIA An understanding of the mechanisms of resistance is key to the effective use of antimicrobials. Knowledge of the mechanism is required to effectively test for resistance. The antibiotic era can…
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Connections Winter 2015 – 2016
VOLUME 19 NUMBER 4 WINTER 2015 - 2016 ISSN 1496-3876 TOE NAIL ONYCHOMYCOSIS Onychomycosis affects over 35 million people in the United States alone; the disease has a prevalence of approximately 3% of the adult population in North America and…
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