Cystoscopic urine: >100 x 10^6 cfu/L Escherichia coli (ESBL positive) – Shipped May 2013
A sample simulating a cystoscopy urine obtained from a 30 year old female out-patient, was sent to category A, B, and C laboratories.
Participants were expected to isolate, report colony count, and identify Escherichia coli as well as report antibiotic susceptibilities.
As this isolate produced an extended spectrum β-lactamase (ESBL), it was also expected laboratories would notify infection control.
MAIN EDUCATIONAL POINTS from M131-1
- ESBL-producing Enterobacteriaceae are becoming more prevalent throughout the world.
- Controversy persists with lower cephalosporin breakpoints in new CLSI and EUCAST guidelines and whether it is necessary to edit susceptibility categories if an ESBL is found.