M201-1

Throat: group A Streptococcus (Streptococcus pyogenes) – Shipped May 11, 2020 – FINAL RESULT

HISTORY

A simulated throat swab sample collected from a 12 year old with a sore throat was sent to category A laboratories.
Participants were expected to isolate and identify group A Streptococcus (Streptococcus pyogenes).

MAIN EDUCATIONAL POINTS from M201-1

  1. S. pyogenes is the most common bacterial etiology of pharyngitis. It causes 15-30% of cases of acute pharyngitis in pediatric and adolescent patients, and 5-10% of cases of acute pharyngitis in adults.
  2. Rapid Antigen Detection Test (RADT) – if a RADT is used, negative throat swabs from children and adolescents should receive reflex culture on blood agar or a nucleic acid amplification test (NAAT) to rule out S. pyogenes. This recommendation arises from the poor to modest sensitivity of RADTs and the potential for S. pyogenes to cause acute rheumatic fever (ARF) and acute glomerulonephritis (AGN) in children and adolescents following infection with this pathogen.

Full critique (PDF)

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