Gram – CSF: mononuclear cells – yeast elements resembling Cryptococcus species
– Shipped February 2014
A simulated cerebrospinal fluid (CSF) smear collected from a 40 year old female patient with severe headache was sent to category A, B, C, and C1 laboratories for Gram staining.
Participants were expected to report the presence of mononuclear cells and yeast elements resembling Cryptococcus species.
MAIN EDUCATIONAL POINTS from GS134-2
- Patients with cryptococcal meningitis frequently present with persistent chronic symptoms consistent with the absence of an acute inflammatory reaction, especially following an environ-mental inhalation exposure to Cryptococcus species.
- The predominant cellular response is most commonly lymphocytes rather than neutrophils, as was found on this slide.